Article
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer.
Genome biology - 15 Sept 2016
Kanu Nnennaya, Cerone Maria Antonietta, Goh Gerald, Zalmas Lykourgos-Panagiotis, Bartkova Jirina, Dietzen Michelle, McGranahan Nicholas, Rogers Rebecca, Law Emily K, Gromova Irina, Kschischo Maik, Walton Michael I, Rossanese Olivia W, Bartek Jiri, Harris Reuben S, Venkatesan Subramanian, Swanton Charles
Abstract excerpt
BACKGROUND: The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range of cancer types. Although many studies have documented the downstream effects of APOBEC3 activity through next-generation sequencing, less is known about their upstream regulation. In this study, we sought to identify a molecular basis for APOBEC3 expression and activation. RESULTS: HER2 amplification and PTEN loss promote...
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