Article

Contrasting genetic predisposition and diagnosis in psychiatric disorders: a multi-omic single-nucleus analysis of the human orbitofrontal cortex

2024-04-24

Abstract excerpt

Psychiatric disorders like schizophrenia, bipolar disorder, and major depressive disorder exhibit significant genetic and clinical overlap. However, their molecular architecture remains elusive due to their polygenic nature and complex brain cell interactions. Here, we integrated clinical data with genetic susceptibility to investigate gene expression and chromatin accessibility in the orbitofrontal cortex of 92 p...

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Literature Corpus work: 4b4dd8b1-c43f-5cdb-b381-a44d31058bc3
DOI: 10.1101/2024.04.24.24306179

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Contrasting genetic predisposition and diagnosis in psychiatric disorders: a multi-omic single-nucleus analysis of the human orbitofrontal cortexDOI 10.1101/2024.04.24.24306179Read

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