Article
Single-nucleus transcriptome-wide association study of human brain disorders.
Nature - 1 Sept 2026
Venkatesh Sanan, Kosoy Roman, Wu Zhenyi, Anyfantakis Marios, Dillard Christian, N M Prashant, Burstein David, Mathur Deepika, Chatzinakos Chris, Ajanaku Bukola, Tsetsos Fotis, Zeng Biao, Gupta Sonali, Bercovitch Rachel, Hong Aram, Casey Clara, Alvia Marcela, Shao Zhiping, Argyriou Stathis, Therrien Karen, Bigdeli Tim, Auluck Pavan, Bennett David A, Marenco Stefano, Haroutunian Vahram, Girdhar Kiran, Bendl Jaroslav, Lee Donghoon, Fullard John F, Hoffman Gabriel E, Voloudakis Georgios, Roussos Panos
Abstract excerpt
Common brain disorders impose a substantial health burden, but localizing their genetic risk in the brain remains challenging1. Although genome-wide association studies have identified numerous loci associated with neuropsychiatric and neurodegenerative disorders, many of these loci lie in non-coding regions that influence gene expression in specific cell types2-5. Traditional bulk brain transcriptomic analyses,...
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- Female
- Humans
- Male
- Brain Diseases