Article

Variant-risk-exon interplay impacts circadian rhythm and dopamine signaling pathway in severe psychiatric disorders

2022-08-11

Abstract excerpt

<h4>ABSTRACT</h4> In psychiatric disorders, common and rare genetic variants cause widespread dysfunction of cells and their interactions, especially in the prefrontal cortex, giving rise to psychiatric symptoms. To better understand these processes, we traced the effects of common and rare genetics, and cumulative disease risk scores, to their molecular footprints in human cortical single-cell types. We demonstra...

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Literature Corpus work: a5abea45-e418-5b32-9259-eb4de66d5a67
DOI: 10.1101/2022.08.09.22278128

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