Article

SingleBrain: A Meta-Analysis of Single-Nucleus eQTLs Linking Genetic Risk to Brain Disorders

2025-03-07

Abstract excerpt

Most genetic risk variants for neurological diseases are located in non-coding regulatory regions, where they may often act as expression quantitative trait loci (eQTLs), modulating gene expression and influencing disease susceptibility. However, eQTL studies in bulk brain tissue or specific cell types lack the resolution to capture the brain’s cellular diversity. Single-nucleus RNA sequencing (snRNA-seq) offers h...

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Literature Corpus work: 40cbc04d-8fe7-5a55-9c00-9813dc9f0dd2
DOI: 10.1101/2025.03.06.25323424

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