Integrating multiomic layers to decode psychiatric disease mechanisms.

Abstract excerpt

Psychiatric disorders such as schizophrenia, bipolar disorder, and major depression are highly polygenic, with most risk variants mapping to the noncoding genome. Emerging multiomic technologies, including single-cell transcriptomics, epigenomics, proteomics, and spatial profiling, now enable integrative analyses that connect genetic variation to gene regulation, cell-type vulnerability, and circuit dysfunction....

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