Article

Single-nucleus transcriptome-wide association study of human brain disorders

2024-11-05

Abstract excerpt

Neuropsychiatric and neurodegenerative disorders exhibit cell-type-specific characteristics 1–8 , yet most transcriptome-wide association studies have been constrained by the use of homogenate brain tissue 9–11 , limiting their resolution and power. Here, we present a single-nucleus transcriptome-wide association study ( snTWAS ) leveraging single-nucleus RNA sequencing of over 6 million nuclei from the dorsolater...

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Literature Corpus work: 7a2c4ea1-f456-5e6a-aaee-57c5a2017a1f
DOI: 10.1101/2024.11.04.24316495

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