Article

Reshuffling yeast chromosomes with CRISPR/Cas9

2018-09-12

Abstract excerpt

<h4>ABSTRACT</h4> Genome engineering is a powerful approach to study how chromosomal architecture impacts phenotypes. However, quantifying the fitness impact of translocations independently from the confounding effect of base substitutions has so far remained challenging. We report a novel application of the CRISPR/Cas9 technology allowing to generate with high efficiency both uniquely targeted and multiple conco...

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Identifiers and source

Literature Corpus work: a64353a3-06f9-5e91-b2ce-ca6af6b4f456
DOI: 10.1101/415349

Open publication

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