Article
Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9.
Journal of molecular cell biology - 1 Aug 2015
Li Jinhuan, Shou Jia, Guo Ya, Tang Yuanxiao, Wu Yonghu, Jia Zhilian, Zhai Yanan, Chen Zhifeng, Xu Quan, Wu Qiang
Abstract excerpt
The human genome contains millions of DNA regulatory elements and a large number of gene clusters, most of which have not been tested experimentally. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated nuclease 9 (Cas9) programed with a synthetic single-guide...
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