Article

Glucocorticoid signaling in pancreatic islets modulates gene regulatory programs and genetic risk of type 2 diabetes

2020-05-16

Abstract excerpt

Glucocorticoids are key regulators of glucose homeostasis and pancreatic islet function, but the gene regulatory programs driving responses to glucocorticoid signaling in islets and the contribution of these programs to diabetes risk are unknown. In this study we used ATAC-seq and RNA-seq to map chromatin accessibility and gene expression from eight primary human islet samples cultured in vitro with the glucocort...

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Literature Corpus work: 4ab6efe5-cbaa-5c21-aecc-d07b560393fc
DOI: 10.1101/2020.05.15.038679

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