Article

Comparative Multi-omic Mapping of Human Pancreatic Islet Endoplasmic Reticulum and Cytokine Stress Responses Provides Insights into Type 2 Diabetes Genetics

2024-02-21

Abstract excerpt

<h4>ABSTRACT</h4> Endoplasmic reticulum (ER) and inflammatory stress responses are two pathophysiologic factors contributing to islet dysfunction and failure in Type 2 Diabetes (T2D). However, how human islet cells respond to these stressors and whether T2D-associated genetic variants modulate these responses is unknown. To fill this knowledge gap, we profiled transcriptional (RNA-seq) and epigenetic (ATAC-seq) r...

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Literature Corpus work: 1cd4c81c-b6de-5397-a1f4-1f31b8147a8d
DOI: 10.1101/2024.02.17.580646

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