Article

Functional characterization of thousands of type 2 diabetes-associated and chromatin-modulating variants under steady state and endoplasmic reticulum stress

2020-02-13

Abstract excerpt

A major goal in functional genomics and complex disease genetics is to identify functional cis- regulatory elements (CREs) and single nucleotide polymorphisms (SNPs) altering CRE activity in disease-relevant cell types and environmental conditions. We tested >13,000 sequences containing each allele of 6,628 SNPs associated with altered in vivo chromatin accessibility in human islets and/or type 2 diabetes risk (...

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Literature Corpus work: 5d14f5a6-1ce5-5e6c-b587-4b5a0e088ec1
DOI: 10.1101/2020.02.12.939348

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