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Large-scale genetic association and single cell accessible chromatin mapping defines cell type-specific mechanisms of type 1 diabetes risk

2021-01-15

Abstract excerpt

<h4>ABSTRACT</h4> Translating genome-wide association studies (GWAS) of complex disease into mechanistic insight requires a comprehensive understanding of risk variant effects on disease-relevant cell types. To uncover cell type-specific mechanisms of type 1 diabetes (T1D) risk, we combined genetic association mapping and single cell epigenomics. We performed the largest to-date GWAS of T1D in 489,679 samples imp...

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Literature Corpus work
312bd66b-c829-55d7-8670-22bbe9d69b76
DOI
10.1101/2021.01.13.426472
Open publication

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Large-scale genetic association and single cell accessible chromatin mapping defines cell type-specific mechanisms of type 1 diabetes riskDOI 10.1101/2021.01.13.426472
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