Article

Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes

2023-01-02

Abstract excerpt

Altered function and gene regulation of pancreatic islet beta cells is a hallmark of type 2 diabetes (T2D), but a comprehensive understanding of mechanisms driving T2D is still missing. Here we integrate information from measurements of chromatin activity, gene expression and function in single beta cells with genetic association data to identify disease-causal gene regulatory changes in T2D. Using machine learnin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9213d927-d455-57c7-a7ca-c5a594bd17cb
DOI: 10.1101/2022.12.31.522386

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetesDOI 10.1101/2022.12.31.522386Read

Single cell chromatin accessibility reveals pancreatic islet cell type- and state-specific regulatory programs of diabetes riskSemantic proximity Read

Single-cell ATAC-Seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signatures.Semantic proximity Read

Single cell ATAC-seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signaturesSemantic proximity Read

Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes riskSemantic proximity Read

Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetesSemantic proximity Read

Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progressionSemantic proximity Read

Single-cell gene expression and chromatin accessibility profiling of human pancreatic islets at basal and stimulatory conditions nominates mechanisms of type 1 diabetes genetic riskSemantic proximity Read

Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation.Semantic proximity Read

Multiomics single-cell analysis of human pancreatic islets reveals novel cellular states in health and type 1 diabetesSemantic proximity Read

Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease GenesSemantic proximity Read

Epigenetic landscapes in human pancreatic islets reveal distinct drivers for adaptation to age and type 2 diabetes.Semantic proximity Read

Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1ASemantic proximity Read