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Article

Glucocorticoid signaling in pancreatic islets modulates gene regulatory programs and genetic risk of type 2 diabetes.

PLoS genetics - 1 May 2021

Aylward Anthony, Okino Mei-Lin, Benaglio Paola, Chiou Joshua, Beebe Elisha, Padilla Jose Andres, Diep Sharlene, Gaulton Kyle J

Abstract excerpt

Glucocorticoids are key regulators of glucose homeostasis and pancreatic islet function, but the gene regulatory programs driving responses to glucocorticoid signaling in islets and the contribution of these programs to diabetes risk are unknown. In this study we used ATAC-seq and RNA-seq to map chromatin accessibility and gene expression from eleven primary human islet samples cultured in vitro with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33983929
DOI: 10.1371/journal.pgen.1009531
PMCID: PMC8183998

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