Back to search

Article

Single cell ATAC-seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signatures

2019-09-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Type 2 diabetes (T2D) is a complex disease characterized by pancreatic islet dysfunction, insulin resistance, and disruption of blood glucose levels. Genome wide association studies (GWAS) have identified >400 independent signals that encode genetic predisposition. More than 90% of the associated single nucleotide polymorphisms (SNPs) localize to non-coding regions and are en...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c18cc677-a820-530e-9059-e228bfccaaa1
DOI
10.1101/749283
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Single cell ATAC-seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signaturesDOI 10.1101/749283
Single-cell ATAC-Seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signatures.Semantic proximity
Single cell chromatin accessibility reveals pancreatic islet cell type- and state-specific regulatory programs of diabetes riskSemantic proximity
Large-scale genetic association and single cell accessible chromatin mapping defines cell type-specific mechanisms of type 1 diabetes riskSemantic proximity
Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetesSemantic proximity
The three-dimensional chromatin structure of the major human pancreatic cell types reveals lineage-specific regulatory architecture of T2D riskSemantic proximity
Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 DiabetesSemantic proximity
CoRE-ATAC: A deep learning model for the functional classification of regulatory elements from single cell and bulk ATAC-seq dataSemantic proximity
Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progressionSemantic proximity
Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes riskSemantic proximity
An integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signalsSemantic proximity
ATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetesSemantic proximity
Single-cell gene expression and chromatin accessibility profiling of human pancreatic islets at basal and stimulatory conditions nominates mechanisms of type 1 diabetes genetic riskSemantic proximity
Select a neighboring publication to make it the new centre.