Article

Single-cell gene expression and chromatin accessibility profiling of human pancreatic islets at basal and stimulatory conditions nominates mechanisms of type 1 diabetes genetic risk

2022-11-13

Abstract excerpt

Type 1 diabetes (T1D) is a complex autoimmune disease characterized by the loss of pancreatic islet beta cells. The mechanisms of T1D genetic risk remain poorly understood. Here, we present a multi-omic integrative study of single-cell/nucleus molecular profiles of gene expression and chromatin accessibility in the same biological samples from healthy and beta cell autoantibody + (AAB+) human pancreatic islets to...

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Literature Corpus work: aca7a347-0a80-5992-93a9-1c9f29360d6e
DOI: 10.1101/2022.11.12.516291

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