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Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights.

Cell metabolism - 5 Nov 2024

Sokolowski Eishani K, Kursawe Romy, Selvam Vijay, Bhuiyan Redwan M, Thibodeau Asa, Zhao Chi, Spracklen Cassandra N, Ucar Duygu, Stitzel Michael L

Abstract excerpt

Endoplasmic reticulum (ER) and inflammatory stress responses contribute to islet dysfunction in type 2 diabetes (T2D). Comprehensive genomic understanding of these human islet stress responses and whether T2D-associated genetic variants modulate them is lacking. Here, comparative transcriptome and epigenome analyses of human islets exposed ex vivo to these stressors revealed 30% of expressed genes and 14% of...

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PMID: 39383866
DOI: 10.1016/j.cmet.2024.09.006

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