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Article

Single-cell ATAC-Seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signatures.

Molecular metabolism - 1 Feb 2020

Rai Vivek, Quang Daniel X, Erdos Michael R, Cusanovich Darren A, Daza Riza M, Narisu Narisu, Zou Luli S, Didion John P, Guan Yuanfang, Shendure Jay, Parker Stephen C J, Collins Francis S

Abstract excerpt

OBJECTIVE: Type 2 diabetes (T2D) is a complex disease characterized by pancreatic islet dysfunction, insulin resistance, and disruption of blood glucose levels. Genome-wide association studies (GWAS) have identified > 400 independent signals that encode genetic predisposition. More than 90% of associated single-nucleotide polymorphisms (SNPs) localize to non-coding regions and are enriched in chromatin-defined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32029221
DOI: 10.1016/j.molmet.2019.12.006
PMCID: PMC6961712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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