Article
Polygenic risk alters the penetrance of monogenic kidney disease
2023-07-19
Abstract excerpt
<title>Abstract</title> <p><bold>Importance</bold> Chronic kidney disease (CKD) is a genetically complex disease determined by an interplay of monogenic, polygenic, and environmental risks. The most common forms of monogenic kidney disorders include autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in the <italic>PKD1</italic> or <italic>PKD2</italic> genes, and COL4A-associated nephropath...
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Identifiers and source
- Literature Corpus work
- 057bb83f-8da9-52f2-98d3-879e018668a9
- DOI
- 10.21203/rs.3.rs-2922940/v1