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Article

Role of Specialized Composition of SWI/SNF Complexes in Prostate Cancer Lineage Plasticity

2020-03-08

Abstract excerpt

Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance observed in ∼10% of these patients is through lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine prostate cancer (NEPC) phenotype. Here, we investigate the role of the mammalian SWI/SNF (mSWI/SNF) chromatin remodel...

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Identifiers and source

Literature Corpus work
49660ace-614d-50de-8816-4373b57edcb1
DOI
10.1101/2020.03.06.949131
Open publication

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Role of Specialized Composition of SWI/SNF Complexes in Prostate Cancer Lineage PlasticityDOI 10.1101/2020.03.06.949131
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