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Article

The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers

6 Mar 2017

Abstract excerpt

Genes encoding subunits of SWI/SNF (BAF) chromatin remodelling complexes are collectively altered in over 20% of human malignancies, but the mechanisms by which these complexes alter chromatin to modulate transcription and cell fate are poorly understood. Utilizing mouse embryonic fibroblast and cancer cell line models, here we show via ChIP-seq and biochemical assays that SWI/SNF complexes are preferentially...

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PMID: 28262751
DOI: 10.1038/ncomms14648

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