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Remodeling the cancer epigenome: mutations in the SWI/SNF complex offer new therapeutic opportunities

15 Apr 2019

Abstract excerpt

INTRODUCTION: Cancer genome sequencing studies have discovered mutations in members of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex in nearly 25% of human cancers. The SWI/SNF complex, first discovered in S. cerevisiae, shows strong conservation from yeast to Drosophila to mammals, contains approximately 10-12 subunits and regulates nucleosome positioning through the energy generated...

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PMID: 30986130
DOI: 10.1080/14737140.2019.1605905

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