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Article

Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity

3 Nov 2020

Abstract excerpt

Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance observed in around 10-20% of these patients is lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine prostate cancer (NEPC) phenotype. Here, we investigate the role of the mammalian SWI/SNF (mSWI/SNF) chromatin...

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PMID: 33144576
DOI: 10.1038/s41467-020-19328-1

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