Article

Multilineage plasticity in prostate cancer through expansion of stem–like luminal epithelial cells with elevated inflammatory signaling

2021-11-03

Abstract excerpt

Lineage plasticity is a well–established mechanism of resistance to targeted therapies in lung and prostate cancer, where tumors transition from adenocarcinoma to small–cell or neuroendocrine carcinoma. Through single–cell analysis of a cohort of heavily–treated castration–resistant human prostate cancers (CRPC), we report a greater degree of plasticity than previously appreciated, with multiple distinct neuroendo...

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Literature Corpus work: 818835ac-1549-51f9-b6ab-c9c5af7a5be2
DOI: 10.1101/2021.11.01.466599

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