Article
Advances in the role of SWI/SNF complexes in tumours.
Journal of cellular and molecular medicine - 1 Apr 2023
Li Ziwei, Zhao Jiumei, Tang Yu
Abstract excerpt
Cancer development is a complex process involving both genetic and epigenetic changes. The SWI/SNF (switch/sucrose non-fermentable) chromatin remodelling complex, one of the most studied ATP-dependent complexes, plays an important role in coordinating chromatin structural stability, gene expression and post-translational modifications. The SWI/SNF complex can be classified into BAF, PBAF and GBAF according to...
Topics
- Humans
- Chromosomal Proteins, Non-Histone
- Transcription Factors
- Neoplasms
- Mutation
- Carcinogenesis
- Chromatin Assembly and Disassembly
