Article

Role of <i>CNC1</i> gene in TDP-43 aggregation-induced oxidative stress-mediated cell death in <i>S. cerevisiae</i> model of ALS

2020-03-05

Abstract excerpt

<h4>ABSTRACT</h4> TDP-43 is a multi-functional ribonucleoprotein that is also found deposited as hyper-phosphorylated and ubiquitinated TDP-43 inclusions in the brain and spinal cord of the patients of the motor neuron diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Till date, how the cell death ensues is not fully deciphered although several molecular mechanisms of the...

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Literature Corpus work: 495080ba-dadf-592f-afe8-6c9885fc0c0a
DOI: 10.1101/2020.03.05.978411

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