Article

A conserved mitochondrial role for cyclin C in mediating oxidative stress-induced cell death in yeast

2025-12-30

Abstract excerpt

Cyclin C is a highly conserved component of the Mediator kinase module that regulates transcription through CDK8 stimulation. In addition, the yeast (Cnc1) and human (CCNC) cyclin C exhibit stress-induced mitochondrial translocation to stimulate fission through direct interaction with the dynamin-like GTPase DRP1 (mammals) or Dnm1 (yeast). Gene ablation studies revealed that both Cnc1 and CCNC are required for cel...

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Literature Corpus work: 0ca67c01-5ee8-5314-a63e-10f4f2f79dd8
DOI: 10.64898/2025.12.30.696989

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