Article

Scp160 deletion suppresses TDP-43 aggregation and toxicity in <i>Saccharomyces cerevisiae</i>

2026-04-29

Abstract excerpt

Protein misfolding and aggregation are central features of neurodegenerative disease, yet the cellular factors that determine whether aggregation-prone proteins become toxic remain incompletely understood. The RNA-binding protein TDP-43 forms cytoplasmic aggregates in amyotrophic lateral sclerosis (ALS) and is toxic when expressed in yeast, providing a tractable model to identify modifiers of TDP-43 proteotoxicity...

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Literature Corpus work: 46c2b018-16de-5c23-a8b7-ccd9a8d4e9af
DOI: 10.64898/2026.04.28.721091

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