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Article

Yeast as a model to study protein misfolding in aged cells

14 May 2018

Abstract excerpt

Yeast models of neurodegenerative diseases associated with protein misfolding and protein aggregation have given unique insights into the underlying genetic and cellular pathomechanisms. These yeast models recapitulate central aspects of protein misfolding and the ensuing toxicity, such as interference with cellular protein quality control, concentration-dependent formation of insoluble, often amyloid-like...

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PMID: 29905793
DOI: 10.1093/femsyr/foy054

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