Article

Dominant toxicity of ALS–FTD-associated <i> CHCHD10 <sup>S59L</sup> </i> is mediated by TDP-43 and PINK1

2019-09-03

Abstract excerpt

Mutations in coiled-coil-helix-coiled-coil-helix domain containing 10 ( CHCHD10 ) are a genetic cause of amyotrophic lateral sclerosis and/or frontotemporal dementia (ALS-FTD). To elucidate how mutations in CHCHD10 induce disease, we generated a Drosophila melanogaster model of CHCHD10 -mediated ALS-FTD. Expression of CHCHD10 S59L in Drosophila caused gain-of-function toxicity in eyes, motor neurons, and mu...

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Literature Corpus work: c2856dae-45b8-5679-a547-5c934bef0313
DOI: 10.1101/753558

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