Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploiting yeast genetics to inform therapeutic strategies for Huntington's disease.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009

Giorgini Flaviano, Muchowski Paul J

Abstract excerpt

Huntington's disease (HD) is a devastating neurodegenerative disorder that is inherited in an autosomal dominant fashion and is caused by a polyglutamine expansion in the protein huntingtin (htt). In recent years, modeling of various aspects of HD in the yeast Saccharomyces cerevisiae has provided insight into the conserved mechanisms of mutant htt toxicity in eukaryotic cells. The high degree of conservation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Evaluation, Preclinical
Share to Huntingtin Protein
Share to Huntington Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Nerve Tissue Proteins

Share to Nuclear Proteins

Share to Protein Folding

Share to Recombinant Proteins

Share to Trinucleotide Repeat Expansion

Source

Identifiers

PMID: 19521824
DOI: 10.1007/978-1-59745-540-4_9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploiting yeast genetics to inform therapeutic strategies for Huntington's disease.PMID 19521824Read ↗

Harnessing the power of yeast to unravel the molecular basis of neurodegenerationSemantic proximity Read ↗

Beer and Bread to Brains and Beyond: Can Yeast Cells Teach Us about Neurodegenerative Disease?Semantic proximity Read ↗

From the Bakery to the Brain Business: Developing Inducible Yeast Models of Human Neurodegenerative DisordersSemantic proximity Read ↗

Yeast as a model to study protein misfolding in aged cellsSemantic proximity Read ↗

Growth assays to assess polyglutamine toxicity in yeast.Semantic proximity Read ↗

Yeast models for amyloid disease.Semantic proximity Read ↗

Contribution of Yeast Models to Neurodegeneration ResearchSemantic proximity Read ↗

Simple is good: yeast models of neurodegenerationSemantic proximity Read ↗

Using yeast models to probe the molecular basis of amyotrophic lateral sclerosis.Semantic proximity Read ↗

From the baker to the bedside: yeast models of Parkinson's diseaseSemantic proximity Read ↗

ALS Yeast Models—Past Success Stories and New OpportunitiesSemantic proximity Read ↗

Yeast models of Parkinson’s disease-associated molecular pathologiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.