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Article

Mechanisms of Cdc48/VCP-mediated cell death: from yeast apoptosis to human disease.

Biochimica et biophysica acta - 1 Jul 2008

Braun Ralf J, Zischka Hans

Abstract excerpt

The evolutionary conserved protein Cdc48/VCP is involved in various cellular processes, such as protein degradation, membrane fusion and chaperone activity. Increased levels of Cdc48/VCP correlate with cancer, whereas Cdc48/VCP at endogenous levels has been proposed to be a pathological effector in protein deposition diseases. Upon mutation Cdc48/VCP triggers the multisystem disorder 'inclusion body myopathy...

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Source

Identifiers

PMID: 18284922
DOI: 10.1016/j.bbamcr.2008.01.015

Genes

VCP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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