Article

Nucleolin rescues TDP-43 toxicity in yeast and human cell models

2020-09-02

Abstract excerpt

<title>Abstract</title> <p>Background TDP-43 is a nuclear protein involved in pivotal processes, extensively studied for its implication in neurodegenerative disorders. TDP-43 cytosolic inclusions are a common neuropathologic hallmark in amyotrophic lateral sclerosis (ALS) and related diseases, and it is now established that TDP-43 misfolding and aggregation play a key role in their etiopathology. TDP-43 neuroto...

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Literature Corpus work: d4a75046-49a7-5cb6-924c-8bfd3a4ecc1e
DOI: 10.21203/rs.3.rs-66117/v1

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