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Article

Protein aggregation and neurodegeneration: clues from a yeast model of Huntington's disease.

Biochemistry. Biokhimiia - 1 Feb 2009

Bocharova N, Chave-Cox R, Sokolov S, Knorre D, Severin F

Abstract excerpt

A number of neurodegenerative diseases are accompanied by the appearance of intracellular protein aggregates. Huntington's disease (HD) is caused by a mutation in a gene encoding huntingtin. The mutation causes the expansion of the polyglutamine (polyQ) domain and consequently polyQ-containing aggregates accumulate and neurons in the striatum die. The role of the aggregates is still not clear: they may be the...

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PMID: 19267681
DOI: 10.1134/s0006297909020163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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