Article

Mutant Cyclin F Impedes COPII Vesicle-Mediated ER-Golgi Trafficking and ER-Associated Degradation, Inducing ER Stress and Golgi Fragmentation in ALS/FTD

2021-08-17

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Mutations in the <italic>CCNF</italic> gene encoding cyclin F are associated with sporadic and familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, but the underlying pathophysiological mechanisms are unknown. Proper functioning of the endoplasmic reticulum (ER) is essential for physiological cellular function. <bold>Methods</bold>We used<bold...

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Literature Corpus work: 26a9176f-b6de-585c-b3ca-9ba310d7c0a6
DOI: 10.21203/rs.3.rs-783450/v1

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