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Article

Expression of an expanded polyglutamine domain in yeast causes death with apoptotic markers.

Biochimica et biophysica acta - 1 Jan 2000

Sokolov Sviatoslav, Pozniakovsky Andrey, Bocharova Natalia, Knorre Dmitry, Severin Fedor

Abstract excerpt

Huntington's disease is caused by specific mutations in huntingtin protein. Expansion of a polyglutamine (polyQ) repeat of huntingtin leads to protein aggregation in neurons followed by cell death with apoptotic markers. The connection between the aggregation and the degeneration of neurons is poorly understood. Here, we show that the physiological consequences of expanded polyQ domain expression in yeast are...

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Identifiers

PMID: 16784720
DOI: 10.1016/j.bbabio.2006.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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