Article

Structure and function of the human apoptotic scramblase Xkr4

2024-08-09

Abstract excerpt

Phosphatidylserine externalization on the surface of dying cells is a key signal for their recognition and clearance by macrophages and is mediated by members of the X-Kell related (Xkr) protein family. Defective Xkr-mediated scrambling impairs clearance, leading to inflammation. It was proposed that activation of the Xkr4 apoptotic scramblase requires caspase cleavage, followed by dimerization and ligand binding....

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Literature Corpus work: 48c669fb-a89e-53cc-b6aa-9906865f351c
DOI: 10.1101/2024.08.07.607004

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