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Article

Structure of the human volume regulated anion channel.

eLife - 10 Aug 2018

Kefauver Jennifer M, Saotome Kei, Dubin Adrienne E, Pallesen Jesper, Cottrell Christopher A, Cahalan Stuart M, Qiu Zhaozhu, Hong Gunhee, Crowley Christopher S, Whitwam Tess, Lee Wen-Hsin, Ward Andrew B, Patapoutian Ardem

Abstract excerpt

SWELL1 (LRRC8A) is the only essential subunit of the Volume Regulated Anion Channel (VRAC), which regulates cellular volume homeostasis and is activated by hypotonic solutions. SWELL1, together with four other LRRC8 family members, potentially forms a vastly heterogeneous cohort of VRAC channels with different properties; however, SWELL1 alone is also functional. Here, we report a high-resolution cryo-electron...

Topics

Amino Acids
HeLa Cells
Humans
Membrane Proteins
Multigene Family
Mutation
Protein Multimerization
Protein Structure, Quaternary
Structure-Activity Relationship
Voltage-Dependent Anion Channels

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Identifiers

PMID: 30095067
DOI: 10.7554/eLife.38461
PMCID: PMC6086657

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