Article

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis

2023-08-23

Abstract excerpt

Efferocytic clearance of apoptotic cells in general, and T cells in particular, is required for tissue and immune homeostasis. Transmembrane mucins are extended glycoproteins highly expressed in the cell glycocalyx that act as a barrier to phagocytosis. Whether and how mucins may be regulated during cell death to facilitate efferocytic corpse clearance is not understood. Here we show that normal and transformed hu...

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Literature Corpus work: abc4edba-ebf0-54b4-b4c5-c1c7d2f6e9a5
DOI: 10.1101/2023.08.22.554267

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