Article

Structure of the human volume regulated anion channel

2018-05-16

Abstract excerpt

SWELL1 (LRRC8A) is the only essential subunit of the Volume Regulated Anion Channel (VRAC), which regulates cellular volume homeostasis and is activated by hypotonic solutions. SWELL1, together with four other LRRC8 family members, forms a vastly heterogeneous cohort of VRAC channels with different properties; however, SWELL1 alone is also functional. Here, we report a high-resolution cryo-electron microscopy stru...

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Literature Corpus work: 68b1c6c4-d4d8-5cff-8b15-d1d9079492ed
DOI: 10.1101/323584

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