Article

Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane

2023-01-17

Abstract excerpt

<title>Abstract</title> <p>Plasma membrane repair defects cause human muscle and heart diseases. In the early stage of membrane repair, TRIM72/MG53 nucleates vesicles to the damaged site within seconds. Despite the therapeutic potential of TRIM72/MG53, the molecular mechanisms are poorly understood. Here, we present the structure of TRIM72, the first complete model of a TRIM E3 ligase. Structure-guided functional...

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Literature Corpus work: 2c85e387-0081-53d0-8593-f2daf2a590d3
DOI: 10.21203/rs.3.rs-403589/v1

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