Article
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.
Nature communications - 13 Apr 2021
Garnish Sarah E, Meng Yanxiang, Koide Akiko, Sandow Jarrod J, Denbaum Eric, Jacobsen Annette V, Yeung Wayland, Samson Andre L, Horne Christopher R, Fitzgibbon Cheree, Young Samuel N, Smith Phoebe P C, Webb Andrew I, Petrie Emma J, Hildebrand Joanne M, Kannan Natarajan, Czabotar Peter E, Koide Shohei, Murphy James M
Abstract excerpt
Phosphorylation of the MLKL pseudokinase by the RIPK3 kinase leads to MLKL oligomerization, translocation to, and permeabilization of, the plasma membrane to induce necroptotic cell death. The precise choreography of MLKL activation remains incompletely understood. Here, we report Monobodies, synthetic binding proteins, that bind the pseudokinase domain of MLKL within human cells and their crystal structures in...
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