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Genetic ablation of a Maurer's cleft protein prevents assembly of the Plasmodium falciparum virulence complex

23 Jun 2011

Abstract excerpt

The malaria parasite Plasmodium falciparum assembles knob structures underneath the erythrocyte membrane that help present the major virulence protein, P. falciparum erythrocyte membrane protein-1 (PfEMP1). Membranous structures called Maurer's clefts are established in the erythrocyte cytoplasm and function as sorting compartments for proteins en route to the RBC membrane, including the knob-associated...

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PMID: 21696460
DOI: 10.1111/j.1365-2958.2011.07740.x

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