Article

A partnership of the lipid scramblase XK and of the lipid transfer protein VPS13A at the plasma membrane

2022-03-30

Abstract excerpt

Chorea-acanthocytosis and McLeod syndrome are diseases with shared clinical manifestations caused by mutations in VPS13A and XK, respectively. Key features of these conditions are the degeneration of caudate neurons and the presence of abnormally shaped erythrocytes. XK belongs to a family of plasma membrane (PM) lipid scramblases whose action results in exposure of PtdSer at the cell surface. VPS13A is an ER-anch...

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Literature Corpus work: a90be697-9a10-57b5-8dca-e8a1798b9271
DOI: 10.1101/2022.03.30.486314

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