Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure.

Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2016

Suzuki Jun, Imanishi Eiichi, Nagata Shigekazu

Abstract excerpt

Xk-related protein (Xkr) 8, a protein carrying 10 transmembrane regions, is essential for scrambling phospholipids during apoptosis. Here, we found Xkr8 as a complex with basigin (BSG) or neuroplastin (NPTN), type I membrane proteins in the Ig superfamily. In BSG(-/-)NPTN(-/-) cells, Xkr8 localized intracellularly, and the apoptosis stimuli failed to expose phosphatidylserine, indicating that BSG and NPTN...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Basigin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biological Transport

Share to Fas Ligand Protein

Share to Glutamic Acid

Share to Leukocytes

Share to Phosphatidylserines

Share to Proteolysis

Source

Open in PubMed Open full text

Identifiers

PMID: 27503893
DOI: 10.1073/pnas.1610403113
PMCID: PMC5003272

Genes

BSG
NPTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure.PMID 27503893Read ↗

Exposure of Phosphatidylserine by Xk-related Protein Family Members during ApoptosisSemantic proximity Read ↗

Structure and function of the human apoptotic scramblase Xkr4Semantic proximity Read ↗

Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells.Semantic proximity Read ↗

A partnership of the lipid scramblase XK and of the lipid transfer protein VPS13A at the plasma membraneSemantic proximity Read ↗

Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion.Semantic proximity Read ↗

Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization.Semantic proximity Read ↗

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosisSemantic proximity Read ↗

Association of XK and Kell Blood Group ProteinsSemantic proximity Read ↗

The cellular phenotype conditions Btk for cell survival or apoptosis signaling.Semantic proximity Read ↗

Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursorsSemantic proximity Read ↗

The Drosophila homolog of the putative phosphatidylserine receptor functions to inhibit apoptosis.Semantic proximity Read ↗

Erythroid differentiation dependent interaction of VPS13A with XK at the plasma membrane of K562 cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.