Article

Sustained mechanical tension governs fibrogenic activation of tendon stromal cells in systemic sclerosis

2021-06-11

Abstract excerpt

Fibrosis is a pathological outcome of aberrant repair responses in systemic sclerosis and affects many tissues, including tendons. Progressive matrix stiffening is a key feature of this pathological remodeling. How dysregulated tissue mechanics contribute to the persistence of the fibrotic phenotype has been obscured by limited availability of experimental tissue models that are both controllable and capture essen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 48b43971-e346-5f52-9426-a1b0d009fd28
DOI: 10.1101/2021.06.11.445955

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sustained mechanical tension governs fibrogenic activation of tendon stromal cells in systemic sclerosisDOI 10.1101/2021.06.11.445955Read

The stiffness-sensitive transcriptome of human tendon stromal cellsSemantic proximity Read

Matrix stiffness regulates profibrotic fibroblast differentiation and fibrotic niche activation in systemic sclerosisSemantic proximity Read

Engineered 3D environments reprogram fibroblast-mediated inflammation in rheumatoid ArthritisSemantic proximity Read

The Stiffness‐Sensitive Transcriptome of Human Tendon Stromal CellsSemantic proximity Read

Human tendon-on-a-chip for modeling vascular inflammatory fibrosisSemantic proximity Read

Mechanical stretch sustains myofibroblast phenotype and function in microtissues through latent TGF-β1 activation.Semantic proximity Read

Mechanical stretch sustains myofibroblast phenotype and function in microtissues through latent TGF-β1 activationSemantic proximity Read

Dynamic hybrid-hydrogel lung models decouple matrix composition, stiffness, and fibroblast memory to define distinct drivers of fibrotic progressionSemantic proximity Read

Regulators of ECM Structure Enable Functional Adaptation to Tensile Loading in Tendon ExplantsSemantic proximity Read

ERK1/2 drives IL-1β-induced expression of TGF-β1 and BMP-2 in torn tendonsSemantic proximity Read

A human synovial tendon-on-a-chip models key features of peritendinous adhesions and offers a new approach methodology for testing anti-fibrotic drugsSemantic proximity Read

CD8+ T cells drive myofibroblast activation and contraction via JAK/STAT3 and TGFβ signalingSemantic proximity Read