Article

Mechanical stretch sustains myofibroblast phenotype and function in microtissues through latent TGF-β1 activation

2020-01-26

Abstract excerpt

Fibrosis is a leading cause of death in developed countries that is characterized by a progressive deterioration of tissue mechanical behavior. Developing methods to study tissue mechanics and myofibroblast activation may lead to new targets for therapeutic treatments that are urgently needed. Microtissue arrays are a promising approach to conduct relatively high throughput research into fibrosis as they recapitul...

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Literature Corpus work: 2c63d9ef-f01f-54e6-b469-0e4e937920e3
DOI: 10.1101/2020.01.25.917179

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