Article

Engineered 3D environments reprogram fibroblast-mediated inflammation in rheumatoid Arthritis

2022-12-21

Abstract excerpt

Inflammation is essential for fighting infections and initiating tissue repair, but chronic unresolved inflammation underlies many conditions, like cancer and autoimmune disorders. While dysregulated immune responses drive chronic inflammation, non-immune stromal cells such as fibroblasts also play a critical role. Targeting fibroblasts could enable tissue-specific therapies while avoiding the systemic suppression...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9463f842-8475-5166-bc11-3c3a2ec990b9
DOI: 10.1101/2022.12.21.521283

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Engineered 3D environments reprogram fibroblast-mediated inflammation in rheumatoid ArthritisDOI 10.1101/2022.12.21.521283Read

Dynamic hybrid-hydrogel lung models decouple matrix composition, stiffness, and fibroblast memory to define distinct drivers of fibrotic progressionSemantic proximity Read

Fibroblast pathology in inflammatory joint diseaseSemantic proximity Read

Review: progression and heterogeneity of multiple sources of mesenchymal stromal cells for the treatment of rheumatoid arthritisSemantic proximity Read

Heterogeneity of Inflammation-associated Synovial Fibroblasts in Rheumatoid Arthritis and Its DriversSemantic proximity Read

Pulmonary Matrix Derived Hydrogels from Patients with Idiopathic Pulmonary Fibrosis Induce a Proinflammatory State in Lung Fibroblasts <i>In Vitro</i>Semantic proximity Read

A 2D inflammatory co-culture model for investigating synovial fibroblast and macrophage interactions in rheumatoid arthritisSemantic proximity Read

Novel fibroblast phenotypes in homeostasis and chronic inflammation: From functions to potential regulators.Semantic proximity Read

Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritisSemantic proximity Read

Biomaterial-based 3D human lung models replicate pathological characteristics of early pulmonary fibrosisSemantic proximity Read

Distinct subsets of synovial fibroblasts control cartilage destruction in joint diseases.Semantic proximity Read

Mechanical tension and integrin alpha 2 beta 1 regulate fibroblast functions.Semantic proximity Read

Dermal fibroblast subsets and their roles in inflammatory and autoimmune skin diseasesSemantic proximity Read