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Article

Matrix stiffness regulates profibrotic fibroblast differentiation and fibrotic niche activation in systemic sclerosis

26 Jun 2025

Abstract excerpt

Objectives Fibrosis progression in systemic sclerosis (SSc) has been attributed to matrix stiffness. Despite extensive research on fibroblast heterogeneity and subset imbalances in fibrotic disorders, the interplay between biomechanical cues and fibroblast dynamics remains largely unexplored. Here, we investigate how matrix stiffness alters fibroblast transcriptional state and influences lineage specification in...

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PMID: 40579317
DOI: 10.1016/j.ard.2025.05.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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